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  • Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy. Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy of Cancer • Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in Gene Therapy • Remaining Obstacles to the Success of Cancer Gene Therapy Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.
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  • Gene Identification means to identify the coding sequence. Gene prediction play vital role to diagnosis various diseases very easily. only coding sequences of genes shows imbalance due to any kind of diseases, whereas non-coding is of no use,it just make the diagnosis complex. so, gene identification gives the exact boundary of coding sequence.Gene identification is a boom in the field of biomedical engineering.
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  • Исполнитель: VINCENT, GENEАльбом: THE VERY BEST OFПроизводитель: EMI GOLD
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  • Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox, globins, olfactory receptors and MHC (immune system) A complete post-genome treatment of the topic originally covered by Ohnos 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways Taps the significant increase in multi-gene family data that has resulted from comparative genomics Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students.
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  • Sometimes life deals us a mediocre hand, then apparently changes the rules of the game without warning. It presents uncomfortable situations, yet seemingly offers little in the way of solutions. Life tears at our hearts and our minds, beating us down physically, mentally, emotionally and spiritually. Is this really the life we were intended to experience? Or is our life just an uncomfortable result of the things we have learned from our experiences and people that have been an influential part of our lives so far? In slightly over 50 pages, Gene reveals some of the basic rules of Life that, if put to use, will make a dramatic difference in how you view life - and in your approach to making those improvements you'd like to make. Discover now, your path to a fulfilling, truly enjoyable lifestyle!
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  • 01. Main Title - Donald Oconnor, Gene Kelly, Debbie Reynolds, The MGM Studio Orchestra 02. Dignity - The MGM Studio Orchestra 03. Fit As A Fiddle (And Ready For Love) - Donald Oconnor, Gene Kelly, The MGM Studio Orchestra 04. Stunt Montage (Extended Version) - The MGM Studio Orchestra 05. First Silent Picture (Extended Version) - The MGM Studio Orchestra 06. Tango (Temptation) - The MGM Studio Orchestra 07. All I Do Is Dream Of You - Debbie Reynolds, The MGM Studio Orchestra 08. Gene Dreams Of Kathy - The MGM Studio Orchestra 09. All I Do Is Dream Of You (Outtake) - Gene Kelly 10. Make Em Laugh - Donald Oconnor 11. Beautiful Girl Montage - Jimme Thompson, The Girl Friends, The MGM Studio Orchestra & Chorus 12. Beautiful Girl - Jimme Thompson 13. Have Lunch With - Me The MGM Studio Orchestra 14. The Stage Is Set - The MGM Studio Orchestra 15. You Were Meant For Me - Gene Kelly 16. You Are My Lucky Star (Outtake) - Debbie Reynolds, The MGM Studio Orchestra 17. Moses - Gene Kelly, Donald Oconnor 18. Good Morning - Donald Oconnor, Gene Kelly, Debbie Reynolds 19. Good Night Kathy - MGM Studio Orchestra 20. Singin In The Rain - Gene Kelly 21. From Dueling To Dancing - The MGM Studio Orchestra 22. Would You? - Betty Noyes 23. Broadway Melody Ballet (Extended Version) - Gene Kelly, The MGM Studio Orchestra And Chorus 24. Would You? End Title - Gene Kelly, Betty Noyes 25. Singin In The Rain (In A-Flat) (Extended Version) - Debbie Reynolds 26. Finale - Gene Kelly, Debbie Reynol...
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  • leaf rust is a wheat disease and the wheat varieties which having leaf rust genes are resistant to it. Lr26 is also a leaf rust resistant gene found in various wheat varieties, having size of 1000 bps. The wheat varieties studied in this research was collected from various locations of Pakistan and observed that those varieties among the collected having Lr26 gene were not only resistant to the disease but also high in yield production and good in other morphological characters.
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  • This text is intended to present information about the medicinal value of the Codonopsis lanceolata, method for high frequency regeneration using different explants and to optimize the factors and conditions required for the gene transformation in Codonopsis lanceoalta which can be routinely used for genetic transformation. Further, γ-TMT gene were introduced for improving the α-tocopherol contents in this plant. As a result, the α-tocopherol content increased in in aerial and subterrenian parts of the transformed Codonopsis lanceolata by over expressing the γ-TMT gene. Antioxidant activities of transgenic and control plants using 1,1-diphenyl-2-picrylhydrazyl (DPPH) analysis and measurement of phenolic compounds, as well as photosynthetic performance were also investigated to ascertain the relationship between changes in the phytochemical profile and photosynthesis rate due to γ-TMT gene overexpression in transgenic plants.
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  • Breeds of cattle have differentiated gene pools. Differentiation was under the effects of selection (for example for the high milk yield), random genetic drift and environmental selection (natural selection). Nowadays, tracking the genes which are known to be associated with the properties of the milk one can identify the status of the breed in relation to the property under consideration. The DGAT1 gene is located in the centromeric end of chromosome 14 in cattle, otherwise known as the acetyl-CoA: diacylglycerol acyltransferase 1(DGAT1), and has been recently identified as a strong candidate gene for milk production traits. This monographph describe various aspect of bovine DGA T1 gene.
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  • Two young slaves are on the run. One makes it, the other gets killed. Travor, who has been dubbed as one of the worst overseers ever, was fired for not coming back with Master Dalton’s prized negro Bobby Gene. he sought employment at Master Wellington’s plantation, who just happened to be Master Dalton’s neighbor. Strange things were happening on Master Wellington’s plantation. It had been brought to his attention that someone had been raiding his property. Nothing of great value; crops, chickens, eggs, as well as a few of the slaves’ attire. A young white couple traveling cross country have fallen on hard times when they are robbed, leaving them only with their personal things. Found themselves in the state of Missouri. Their names are Jeffrey and Pauline Turner, ended up taking what they thought was temporary residency. It became something different. Wellington put Jeffrey in charge of finding out who this mysterious person was who had been raiding his property.Several months of staying in the loft. Jeffrey was ready for it to be over. Gets his wish when he happens to see someone running through the dried-up fields. Took out in pursuit of this person. Bringing him to a cave. Discovering he’s black, and his name is Bobby Gene, they became the best of friends. Bobby Gene and Anna Belle are reunited through Jeffrey. The three come up with a plan to get Bobby Gene safely to the north. Jeffrey seeks work in town at the saw mill after finding Pauline and Matthew in bed together.B...
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  • Gene Containment provides a comprehensive look at genetically modified organisms and the strategies and implementation of key methods to gene containment. The book is divided into 5 parts: An Introduction that discusses the need for biotechnology and GMOs, Section 1 looks at the need for gene containment, Part II discusses varying strategies for gene containment, section III explores the assessment of gene containment approaches, and section IV covers the steps involved in implementing gene containment. Gene Containment will provide a thorough and up to date look at gene containment research and the needs for implementing new strategies in this arena.
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  • This quintessentially American story of adventure, hope and healing, displays Gene Stratton-Porter's characteristic blend of optimism and faith in nature. It has inspired several movies.
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  • It was emphasized to engineering abiotic stress tolerance in blackgram by overexpression of the glyoxalase I gene isolated from Brassica juncea under a most widely used CaMV 35S promoter. We have demonstrated for the first the applicability of the glyoxalase system in imparting abiotic stress tolerance in a crop legume Vigna mungo. The transgenic lines were confirmed for gene insertion using different molecular techniques. The expression pattern of the inserted gene/s confirmed the expression and activity of the gene in the all transgenic lines studied up to T2 generations. The in vitro raised plants are usually sensitive to hardening process as well as transplantation. In case of blackgram, the survival rate during hardening and the transplantation was ca. 65-70%. To improve the percentage survival of plants, plant growth promoting Rhizobium and Arbuscular Mycorrhizal fungi were applied during the hardening and transplantation. This resulted in overall survival rate of plants up to 90% in both the transgenics as well as the untransformed control plants. Effect of Rhizobium and Mycorrhiza on transgenic as well as the untransformed control plants was studied. We reported for the first time that the transgenic nature of the plant does not affect association of the plant growth promoting Rhizobacteria or Mycorrhiza. Alleviates transplantation shock of in vitro grown Vigna mungo plants was also observed.
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  • In 1935 geneticist Nikolai Timoféeff-Ressovsky, radiation physicist Karl G. Zimmer, and quantum physicist Max Delbrück published “On the Nature of Gene Mutation and Gene Structure,” known subsequently as the “Three-Man Paper.” This seminal paper advanced work on the physical exploration of the structure of the gene through radiation physics and suggested ways in which physics could reveal definite information about gene structure, mutation, and action. Representing a new level of collaboration between physics and biology, it played an important role in the birth of the new field of molecular biology. The paper’s results were popularized for a wide audience in the What is Life? lectures of physicist Erwin Schrödinger in 1944. Despite its historical impact on the biological sciences, the paper has remained largely inaccessible because it was only published in a short-lived German periodical. Creating a Physical Biology makes the Three Man Paper available in English for the first time. Brandon Fogel’s translation is accompanied by an introductory essay by Fogel and Phillip Sloan and a set of essays by leading historians and philosophers of biology that explore the context, contents, and subsequent influence of the paper, as well as its importance for the wider philosophical analysis of biological reductionism.Издательство - The University of Chicago Press
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  • Consistency modeling for gene selection is a new topic emerging from recent cancer bioinformatics research. The result of classification or clustering on a training set was often found very different from the same operations on a testing set. Here, the issue is addressed as a consistency problem. In practice, the inconsistency of microarray datasets prevents many typical gene selection methods working properly for cancer diagnosis and prognosis. In an attempt to deal with this problem, a new concept of performance-based consistency is proposed in this thesis. The proposed consistency concept has been investigated on eight benchmark microarray and proteomic datasets. The experimental results show that the different microarray datasets have different consistency characteristics, and that better consistency can lead to an unbiased and reproducible outcome with good disease prediction accuracy.
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  • This book illustrates the benefits of plastid engineering over nuclear transformations using chloroplast preferred codon optimized cry1 Ab gene equally expressing in nucleus as well, in model plant tobacco. Not only gene insertion was confirmed but also the gene expression was analyzed. A number of valuable agronomic traits such as improved crop yield, sustainability, tolerance to drought, salt, herbicide and insect resistance etc can be engineered easily in plastome rather than in nucleus. The problem of gene escape is not observed in plastid transformations hence, reducing general public concern of establishing "super weeds". Transplastomics have generated a new era of Green technology opening attractive avenues for bio technologists.
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  • Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.
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  • Edward and Gene were instantly drawn to each other when they met at college in Maryland. Fast friends, they developed a "closer than brothers" relationship. But then Edward began to feel more for Gene. In 1967, those kind of feelings would not be tolerated. Not even by Edward himself. Gene always thought he was asexual. He had never been attracted to anyone... until he met Edward. He dreamed of Edward as more than a friend throughout college, but he knew Edward would not welcome that kind of attention. So Gene wasn't surprised when Edward reacted badly to a drunken kiss just before Edward's graduation. He was surprised when Edward moved to Florida and had little to do with him for years afterward. When fate finally brings them back together, Edward is married and has a little girl. Gene gladly accepts the role of "Uncle Gene," happy to have Edward in his life in any capacity. Together, they face all the trials and tribulations life throws at them, including the death of Edward's wife, and as each grows and matures, their life views change. The relationship they've secretly wanted all along is closer than ever, and if Edward can break free from his homophobic upbringing and admit his feelings for Gene, there might still be a chance for them to share their lives in the way they both desire. A Bittersweet Dreams title: It's an unfortunate truth: love doesn't always conquer all. Regardless of its strength, sometimes fate intervenes, tragedy...
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  • Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.
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  • Bachelor Thesis from the year 2014 in the subject Computer Science - Bioinformatics, grade: 8.26, Lovely Professional University, Punjab, course: b.tech honors biotechnology, language: English, abstract: As the number of genomes sequenced is increasing at high rate, there is a need of gene prediction method which is quick, reliable, inexpensive. In such conditions, the computations tool will serve as an alternative to wet lab methods. The confidence level of annotation by the tool can be enhanced by preparing exhaustive training data sets. The aim is to develop a tool which will read data from a DNA sequence file in the fasta format and will annotate it. For this purpose Genome Database was used to retrieve the input data. PERL programming has been put to develop this tool for annotation. To increase the confidence level of annotation the data was validated from multiple sources. Perl script was written to find the promoter region, repeats, transcription factor binding site, base periodicity, and nucleotide frequency. The program written was also executed to identify repeats, poly (A) signals, CpG islands, ARS. The tool will annotate the DNA by predicting the gene structure based on the consensus sequences of important regulatory elements. The confidence level of annotation of the predicted gene, non-coding region, ARS, repeats etc. were checked by running test dataset. This test dataset was annotated data as reported by genome database and computational tools. Gene predictio...
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  • A works researched for a phased process of investing and introducing the cashless society.An attempt for real options applications as applicable as real -world
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  • This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the worlds leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.
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  • In The Selfish Gene, Richard Dawkins crystallized the gene's eye view of evolution developed by W.D. Hamilton and others. The book provoked widespread and heated...
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  • Genes, which are carried on chromosomes are the basic physical and functional units of heredity. In humans, genes are compressed and bundled into a set of 23 pairs of chromosomes, which stabilize and protect the DNA. Gene therapy is an emerging field of biomedicine that has commanded considerable scientific and popular attention. Gene therapy is the insertion, alteration, or removal of genes within an individual's cells and biological tissues to treat disease. It is a technique for correcting defective genes that are responsible for disease development.Gene therapy is having a pervasive and significant impact on areas related to science-based dental practice. Biological research is presenting dentists with more potential treatment options for the future. Gene therapy is in its infancy, and current gene therapy is primarily experimental, with most human clinical trials only in the research stages. Over time and with proper oversight, human gene therapy might become an effective weapon in modern medicine's arsenal to help fight various diseases.
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  • The transposable genetic elements, or transposons, as they are now known, have had a tumultuous history. Discovered in the mid-20th century by Barbara McClintock, they were initially received with puzzlement. When their genomic abundance began to be apparent, they were categorized as «junk DNA» and acquired the label of parasites. Expanding understanding of gene and genome organization has revealed the profound extent of their impact on both. Plant Transposons and Genome Dynamics in Evolution captures and distills the voluminous research literature on plant transposable elements and seeks to assemble the big picture of how transposons shape gene structure and regulation, as well as how they sculpt genomes in evolution. Individual chapters provide concise overviews of the many flavors of plant transposons and of their roles in gene creation, gene regulation, development, genome evolution, and organismal speciation, as well as of their epigenetic regulation. This volume is essential reading for anyone working in plant genetics, epigenetics, or evolutionary biology.
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  • Gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, microarrays have been used to obtain global views of human cancer gene expression and identify genetic markers that might be important for diagnosis and therapy. The initial sequencing of the human genome, coupled with technological advances, now make it possible to embrace the genetic complexity of common human cancers in global fashion. Tools are currently available, or are being developed, for the identification of all changes that take place in cancer at the DNA, RNA, and protein levels. In particular, the use of microarrays for the comprehensive analysis of RNA expression in human tumor samples holds much promise.
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  • Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
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  • This study sets out to analyze transgenic animals in which amelotin is expressed throughout all stages of enamel formation (amelogenesis). Tooth development is a very intricate process, and amelotin is an enamel-specific gene product, which under normal expression is limited to the maturation stage of amelogenesis. In this study, the altered pattern of amelotin gene expression is achieved by creating transgenic mice in which the amelogenin gene promoter is used to drive amelotin.
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